The information store could not be opened in Outlook

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Some users have posted on Microsoft’s forum about the information store could be opened error that arises when they try to launch Outlook.
There are a few variations of that error message for the different Outlook versions. For Outlook 2019 and ‘16 users, the full error message states:
Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened. The information store could not be opened.
Here are some more related issues reported by our readers. Make sure you go through the list and see if any of these cases apply to you.
Where and when does this error occur?
- Outlook 365/Office 365 The information store cannot be opened
- The specified default store cannot be opened
- The information store could not be opened Exchange 2016/2013
- The information store could not be opened Outlook 2016/2019/2013/2007
- Cannot start Microsoft Outlook (A clear indicator of this error is when Outlook simply refuses to open).
- The information store could not be opened iCloud
- The set of folders cannot be opened
As a result, users can’t open Outlook. There are, however, numerous potential fixes for the information store cannot be opened error. Check out some of the resolutions below to fix the information store issue.
How can I fix the Information Store Error?
1. Open Outlook in Safe Mode
First, try opening Outlook in Safe Mode. Press the Windows key + R hotkey. Then enter ‘Outlook /safe’ in the Open box and click OK.

2. Deselect the Compatibility Mode Option

3. Fix the Navigation Pane File
The information store error can be due to corrupted navigation pane settings. To fix that, press the Windows key + R keyboard shortcut. Then enter outlook.exe /resetnavpane in Run’s Open text box, and press the OK button.

4. Fix Outlook’s PST File

5. Remove Lync From the System Startup

6. Clean Boot Windows


Those resolutions will probably fix the information store cannot be opened error for lots of users. Outlook users can also check out the Microsoft Support and Recovery Assistant utility, which might also fix the information store error.
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